These are related to the mechanism of methylxanthine, caffeine and aminophylline are both central nervous system stimulants. Steer similarly concluded that in the short term, caffeine was as effective as aminophylline in reducing the incidence of apnea and was better tolerated and easier to administer. We believe that caffeine and aminophylline treatments are equivalent effective in reducing apnea of prematurity, which has been confirmed in several independent studies. But the rates of hyperglycemia were similar between the caffeine and aminophylline groups. The results indicated that caffeine was as effective as aminophylline in terms of treating AOP, the occurrence of tachycardia and feeding intolerance in the caffeine group was clearly less than that in the aminophylline group. Therefore, our meta-analyses aimed to assess the comparative efficacy and safety of caffeine and aminophylline in the treatment of AOP. What’s more, aminophylline is effective in improving the renal function of asphyxiated neonates. But the present findings reported that there is no difference between caffeine and aminophylline in terms of incidence apneic, bradycardic or hypoxemic. It is well known that caffeine has a wider effectiveness as well as less adverse effects than aminophylline, and does not require routine blood concentration measurements. Limited information was available for extracting or duplicating data.Īlthough methylxanthine has been widely administered in many countries for the treatment of AOP, the choice between caffeine and aminophylline is still controversial.Unclear or inappropriate definition of exposure/results.Reviews, case reports, meeting abstracts, animal trials, or trial registration reports.In this meta-analysis, any of the following literature that met the exclusion criteria were excluded: The diagnosis of feeding intolerance and hyperglycemia relies on the documentation of medical or surgical data.
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